CDNF rescues motor neurons in three animal models of ALS by targeting ER stress
Francesca De Lorenzo, Patrick Lüningschrör, Jin Han Nam, Federica Pilotto, Emilia Galli, Päivi Lindholm, Cora R. von Collenberg, Simon Tii Mungwa, Sibylle Jablonka, Julia Kauder, Susanne Petri, Dan Lindholm, Smita Saxena, Michael Sendtner, Märt Saarma, Merja H. Voutilainen
This study shows CDNF reduces ER stress and improves motor neuron survival in multiple ALS models, independent of genetic cause.
bioRxiv · May 5, 2020 · PreprintNeuroscience