Author

Julian Knight

Centre for Human GeneticsPrimary ORCID profile (0000-0002-0377-5536 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Julian KnightiD1 paper · Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom;

Biology Disciplines

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Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:deconvolution· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Elie AntouniD· 2 shared Tao DongiD· 2 shared Yanchun PengiD· 2 shared Alexander J. MentzeriD· 1 shared Craig WaughiD· 1 shared Deshni JayathilakaiD· 1 shared Fadi IssaiD· 1 shared George AdigbliiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBioinformatics

Elie AntounORCID

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2 papers

Recent·Most cited

ClonoDeconv: reference-based α - β paired recurrent clonotype proportion estimation from bulk-TCR sequencing

Yuze Zhou, Elie Antoun, Mariana Pereira Pinho, Jianqing Zheng, Yuxi Wu, George Adigbli, Fadi Issa, Yanchun Peng, Julian Knight, Tao Dong

ClonoDeconv estimates paired TCR clonotype proportions from bulk-TCR sequencing using a single-cell reference, capturing longitudinal T-cell clonal dynamics.

bioRxiv · Oct 19, 2026 · PreprintBioinformatics

Mode of T cell priming durably shapes the TCR repertoire, effector function and α4β1 integrin expression of human virus-specific CD4+ T cells

Elie Antoun, Guihai Liu, Deshni Jayathilaka, Xuan Yao, Timothy Rostron, Craig Waugh, Kevin Clark, Paul Sopp, Jeremy W. Fry, Tianyi Xia, Alexander J. Mentzer, Julian Knight, Yanchun Peng, Tao Dong

This study compares how natural infection versus vaccination primes human CD4+ T cells, showing differences in TCR diversity, effector function, and integrin expression years later.

bioRxiv · Aug 19, 2026 · PreprintImmunology