Xuan Yao

Mode of T cell priming durably shapes the TCR repertoire, effector function and α4β1 integrin expression of human virus-specific CD4+ T cells

This study compares how natural infection versus vaccination primes human CD4+ T cells, showing differences in TCR diversity, effector function, and integrin expression years later.

HDOCK-Multimer: integrating docking and combinatorial assembly for structure prediction of large protein complexes

HDOCK-Multimer improves prediction of large protein complexes by combining docking and combinatorial assembly, outperforming existing methods on benchmark datasets.

Uncovering structural determinants of peptide recognition by public and private T-cell receptors

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.