Tao Dong

ClonoDeconv: reference-based α - β paired recurrent clonotype proportion estimation from bulk-TCR sequencing

ClonoDeconv estimates paired TCR clonotype proportions from bulk-TCR sequencing using a single-cell reference, capturing longitudinal T-cell clonal dynamics.

Mode of T cell priming durably shapes the TCR repertoire, effector function and α4β1 integrin expression of human virus-specific CD4+ T cells

This study compares how natural infection versus vaccination primes human CD4+ T cells, showing differences in TCR diversity, effector function, and integrin expression years later.

Uncovering structural determinants of peptide recognition by public and private T-cell receptors

The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.