Cardiomyopathy-Associated and Basic Residue Mutations in Myopalladin Alter Actin Binding, Bundling, and Structural Stability
Asha Rankoth Arachchige, Julie Tran, Ziwei Zhao, Hannah Dammann, Alia Michaelis, Vinay Kumar Kadarla, Michal Žółkiewski, Erika R. Geisbrecht, Moriah Rene Beck
This paper identifies conserved basic residue clusters in the Ig3 domain of myopalladin (MYPN) critical for actin binding and bundling, showing that cardiomyopathy-associated mutations disrupt these interactions and lead to abnormal subcellular localization.
Protein Science · Jan 24, 2026Peer-reviewedBiochemistry