Neoantigen-reactive CD8+ T cell engagement marks exceptional survivors of pancreatic cancer
Marc Hilmi, Joshua David Schoenfeld, Wilson McKerrow, Yuval Elhanati, Catherine A. O’Connor, Shigeaki Umeda, Nicolas Lecomte, Jerry P. Melchor, Agustin Cardenas, Maria Lao, Vincenzo Nasca, Elias-Ramzey R. Karnoub, Nuray Tezcan, Zeynep Cagla Tarcan, Joanne F. Chou, , Wungki Park
The paper identifies TIE CD8+ T cell clonotypes associated with prolonged survival in pancreatic cancer patients and links resistance to stromal and immune barriers.
bioRxiv · Sep 18, 2026 · PreprintCancer Biology