High-Content Screening Identifies Dithiocarbamates As A Class Of Chemicals That Disrupts TDP-43 Proteostasis
Giulia Fragola, Ryan D. Weeks, Justin Wolter, Audra F. Bryan, Katheryn Natalya Kapfer, Xu Tian, Julie Necarsulmer, Baggio Evangelista, Vanya Bhat, Omeed K Arooji, Adriana S. Beltrán, Tara A. Brennan, Matthew J. Niederhuber, Austin J. Hepperla, Leonard B. Collins, , Todd J Cohen
This study identifies dithiocarbamates as chemicals that disrupt TDP-43 proteostasis by causing aggregation and loss of function through redox imbalance and zinc homeostasis disruption.
bioRxiv · Aug 22, 2026 · PreprintNeuroscience