Adriana S. Beltrán

High-Content Screening Identifies Dithiocarbamates As A Class Of Chemicals That Disrupts TDP-43 Proteostasis

This study identifies dithiocarbamates as chemicals that disrupt TDP-43 proteostasis by causing aggregation and loss of function through redox imbalance and zinc homeostasis disruption.

Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast Cancer

This study shows vandetanib enhances tamoxifen sensitivity in ER+ breast cancer by reprogramming ER gene regulation and kinase networks, identifying adaptive resistance pathways and response signatures.

A Multimodal Framework to Uncover Drug-Responsive Subpopulations in Triple-Negative Breast Cancer

This paper introduces a multimodal framework to identify drug-responsive subpopulations in triple-negative breast cancer by integrating bulk and single-cell transcriptomics data.

Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories

The paper links early cell cycle gene expression in cortical organoids to interindividual variability in infant brain growth trajectories.

Single-cell dynamics of core pluripotency factors in human pluripotent stem cells

This study uses CRISPR/Cas9 and microraft arrays to track OCT4, SOX2, and NANOG dynamics in human stem cells during differentiation, revealing spatiotemporal patterns in germ layer formation.

Inheritance of OCT4 predetermines fate choice in human embryonic stem cells

The paper shows that OCT4 inheritance predetermines fate choice in human embryonic stem cells, with higher OCT4 ratios in daughters leading to sustained pluripotency and reduced differentiation potential.