Author

K. A. Freitas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. L. Mackall· 3 shared E. Sotillo· 3 shared P. Xu· 3 shared A. Leruste· 2 shared A. T. Satpathy· 2 shared B. Daniel· 2 shared J. Huang· 2 shared K. Sandor· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

C. L. Mackall

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineered CD47 protects T cells for enhanced antitumor immunity

S. A. Yamada-Hunter, J. Theruvath, B. J. McIntosh, K. A. Freitas, M. T. Radosevich, A. Leruste, S. Dhingra, N. Martinez-Velez, P. Xu, A. Delaidelli, M. H. Desai, Z. Good, L. Labanieh, C. W. Mount, Y. Chen, , C. L. Mackall

This paper engineers a CD47 variant to protect T cells from macrophage clearance, enhancing antitumor efficacy by combining T cell and macrophage activation.

bioRxiv · Jun 20, 2023 · PreprintBioengineering

Inosine Induces Stemness Features in CAR T cells and Enhances Potency

D. D. Klysz, C. Fowler, M. Malipatlolla, L. Stuani, K. A. Freitas, S. Meier, B. Daniel, K. Sandor, P. Xu, J. Huang, L. Labanieh, A. Leruste, M. Bashti, V. Keerthi, J. Mata-Alcazar, , C. L. Mackall

This study shows that inosine enhances CAR T cell stemness and function by modulating metabolism and epigenetics, leading to improved anti-tumor potency.

bioRxiv · Apr 21, 2023Immunology

Enhanced Effector Activity of Mediator Kinase Module Deficient CAR-T Cells

K. A. Freitas, J. A. Belk, E. Sotillo, B. Daniel, K. Sandor, D. Klysz, V. T. Duong, K. A. Burdsall, P. Xu, M. Malipatlolla, M. G. Donovan, E. W. Weber, R. G. Majzner, H. Y. Chang, J. M. Espinosa, , C. L. Mackall

This study identifies the Mediator kinase module as a regulator of T cell differentiation and shows that its inhibition enhances effector T cell potency.

bioRxiv · Sep 2, 2022 · PreprintImmunology