Author

J. A. Belk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. T. Satpathy· 4 shared H. Y. Chang· 4 shared B. Daniel· 3 shared Y. Qi· 3 shared K. Sandor· 2 shared A. G. Chemparathy· 1 shared A. G. Henssen· 1 shared A. Limaye· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersImmunology

A. T. Satpathy

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Coordinated inheritance of extrachromosomal DNA species in human cancer cells

K. L. Hung, M. G. Jones, I. T.-L. Wong, J. T. Lange, J. Luebeck, E. Scanu, B. J. He, L. Brückner, R. Li, R. C. Gonzalez, R. Schmargon, J. R. Dörr, J. A. Belk, V. Bafna, B. Werner, , H. Y. Chang

This study shows that multiple extrachromosomal DNA species are coordinately inherited in cancer cells through mitotic co-segregation, enabling oncogene cooperation and guiding therapeutic strategies.

bioRxiv · Jul 18, 2023 · PreprintCancer Biology

Enhanced Effector Activity of Mediator Kinase Module Deficient CAR-T Cells

K. A. Freitas, J. A. Belk, E. Sotillo, B. Daniel, K. Sandor, D. Klysz, V. T. Duong, K. A. Burdsall, P. Xu, M. Malipatlolla, M. G. Donovan, E. W. Weber, R. G. Majzner, H. Y. Chang, J. M. Espinosa, , C. L. Mackall

This study identifies the Mediator kinase module as a regulator of T cell differentiation and shows that its inhibition enhances effector T cell potency.

bioRxiv · Sep 2, 2022 · PreprintImmunology

A unique epigenomic landscape defines CD8+ tissue-resident memory T cells

F. A. Buquicchio, R. Fonseca, J. A. Belk, M. Evrard, A. Obers, Y. Qi, B. Daniel, K. E. Yost, A. T. Satpathy, L. K. Mackay

This study identifies distinct epigenetic trajectories in CD8+ T cells during acute infection, revealing how chromatin accessibility changes guide the development of tissue-resident memory T cells versus circulating memory T cells.

bioRxiv · May 4, 2022 · PreprintImmunology

Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state

B. Daniel, J. A. Belk, S. L. Meier, A. Y. Chen, K. Sandor, Y. Qi, H. Kitano, J. R. Wheeler, D. S. Foster, M. S. Januszyk, M. T. Longaker, H. Y. Chang, A. T. Satpathy

This study shows that macrophage inflammatory and regenerative responses are phase-dependent on the cell cycle, with S-G2/M phases linked to tissue remodeling and reduced IFNG-induced repolarization.

bioRxiv · Jun 24, 2021Immunology

Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection

R. A. Flynn, J. A. Belk, Y. Qi, Y. Yasumoto, C. O. Schmitz, M. R. Mumbach, A. Limaye, J. Wei, M. M. Alfajaro, K. R. Parker, H. Y. Chang, T. L. Horvath, J. E. Carette, C. Bertozzi, C. B. Wilen, A. T. Satpathy

This study identifies 309 host proteins interacting with SARS-CoV-2 RNA during infection and reveals their roles in virus-induced cell death and mitochondrial dysfunction.

bioRxiv · Oct 6, 2020 · PreprintMicrobiology

Leveraging non-structural data to predict structures of protein-ligand complexes

J. M. Paggi, J. A. Belk, S. A. Hollingsworth, N. Villanueva, A. S. Powers, M. J. Clark, A. G. Chemparathy, J. E. Tynan, T. K. Lau, R. K. Sunahara, R. O. Dror

This paper presents a statistical framework combining physics-based and ligand-based methods to predict protein-ligand complex structures, improving pose prediction accuracy for drug targets.

bioRxiv · Jun 1, 2020 · PreprintBiophysics