Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCFSlmb degron
K. M. Gray, K. A. Kaifer, D. Baillat, Y. Wen, T. R. Bonacci, A. D. Ebert, A. C. Raimer, A. M. Spring, S. ten Have, J. J. Glascock, K. Gupta, G. D. Van Duyne, M. J. Emanuele, A. I. Lamond, E. J. Wagner, , A. G. Matera
The paper identifies SCFSlmb as a regulator of SMN protein stability through a degron, showing that self-oligomerization stabilizes SMN isoforms and mitigates SMA severity.
bioRxiv · Sep 30, 2016Biochemistry