A. I. Lamond

Assembly of mTORC3 involves binding of ETV7 to two separate sequences in the mTOR kinase domain.

This study identifies mTORC3, a rapamycin-resistant mTOR complex that requires ETV7 binding, and shows that specific mTOR and ETV7 domains mediate this interaction, with implications for cancer therapy.

Systematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

This paper develops a workflow to identify proline hydroxylation sites using HILIC and LC-MS, finding 4,993 and 3,247 sites in HEK293 and RCC4 cells, respectively.

Screening for variable drug responses using human iPSC cohorts

The paper develops a drug screening platform using hiPSC lines from different donors to predict variable drug responses and mechanisms, showing potential for improving drug safety across diverse genetic backgrounds.

Native size exclusion chromatography-based mass spectrometry (SEC-MS) identifies novel components of the Heat Shock Protein 90-dependent proteome

This study uses SEC-MS to analyze HSP90 inhibitor effects on protein complexes, identifying both known and novel components of the HSP90-dependent proteome.

Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA

The paper identifies reader proteins for 5-methylcytosine and its derivatives in C. elegans RNA using modified RNA baits and mass spectrometry.

Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response

This study shows Nrf2 regulates macrophage metabolism, redox balance, and inflammatory responses, with 4-OI modulating these effects through Nrf2.

Tissue environment, not ontogeny, defines intestinal intraepithelial T lymphocytes

The paper uses proteomic analysis to show that the gut environment, not developmental origin, shapes the functional properties of intestinal intraepithelial T lymphocytes.

Cyclin A triggers Mitosis either via Greatwall or Cyclin B

This study shows Cyclin A can trigger mitosis through Greatwall or Cyclin B by regulating Cdk1 activity and phosphorylation of mitotic substrates.

Direct interaction of PIWI and DEPS-1 is essential for piRNA function and condensate ultrastructure in Caenorhabditis elegans

The paper investigates how PIWI and DEPS-1 interact to support piRNA function and condensate structure in C. elegans.

Antigen receptor control of methionine metabolism in T cells

This study shows antigen receptor engagement controls methionine cycle flux and methyl donor availability for RNA and histone methylation in T cells.

Optimising multi-batch TMT analysis to mitigate inflation of missing values, false positives and diminished inter batch accuracy

The paper evaluates the impact of integrating multiple TMT batches in proteomic analysis and proposes solutions to reduce missing values, false positives, and inter-batch accuracy issues.

The iPSC proteomic compendium

The paper presents a proteomic analysis of 217 HipSci iPSC lines, identifying >16,000 protein groups and their roles in iPSC biology.

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28gamma

This paper identifies PIP30/FAM192A as a novel cofactor of PA28gamma, showing it binds to PA28gamma and modulates its interactions with the 20S proteasome and coilin.

Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS

The paper uses PRIMMUS to analyze proteomic changes during cell cycle progression, identifying phosphorylation sites and their roles in mitotic progression.

Characterisation Of The Biflavonoid Hinokiflavone As A Pre-mRNA Splicing Modulator That Inhibits SENP

This study identifies hinokiflavone as a splicing inhibitor that modulates alternative splicing by inhibiting SUMO protease SENP1 and altering SUMOylation of splicing factors.

Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCFSlmb degron

The paper identifies SCFSlmb as a regulator of SMN protein stability through a degron, showing that self-oligomerization stabilizes SMN isoforms and mitigates SMA severity.