K. A. Morano

Cytoplasmic redox imbalance in the thioredoxin system activates Hsf1 and results in hyperaccumulation of the sequestrase Hsp42 with misfolded proteins

This study shows that disrupting the cytosolic thioredoxin system in yeast activates Hsf1 and causes Hsp42 to hyperaccumulate with misfolded proteins, leading to growth defects under oxidative stress.

Redox regulation of yeast Hsp70 modulates protein quality control while directly triggering an Hsf1-dependent cytoprotective response

This study shows that redox regulation of yeast Hsp70 affects protein quality control and activates Hsf1-dependent stress responses through cysteine modifications.

Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones

This study identifies a novel intrinsically disordered region in metazoan Hsp110 chaperones that suppresses protein aggregation and amyloid formation.