Author

K. A. Nasmyth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 4 Research Focus:cell signaling & trafficking· 3 Approach:biophysical modeling· 2 Research Focus:protein folding & dynamics· 2 Assay:ATAC-seq· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

M. Voulgaris· 3 shared B.-G. Lee· 2 shared J. E. Collier· 2 shared M. Srinivasan· 2 shared N. J. Petela· 2 shared A. Gonzalez Llamazares· 1 shared A. Kaushik· 1 shared B. Hu· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

M. Voulgaris

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

What Alphafold tells us about cohesin's retention and release from chromosomes

K. A. Nasmyth, B.-G. Lee, M. B. Roig, J. Löwe

This paper uses AlphaFold 2 to propose a molecular mechanism for cohesin retention and release from chromosomes involving Wapl, SA, Pds5, and Scc1 interactions.

bioRxiv · Apr 14, 2023Biochemistry

Conformational dynamics of cohesin/Scc2 loading complex are regulated by Smc3 acetylation and ATP binding

A. Kaushik, T. Than, N. J. Petela, M. Voulgaris, C. Percival, P. Daniels, J. B. Rafferty, K. A. Nasmyth, B. Hu

This study identifies how Smc3 acetylation and ATP binding regulate the dynamic conformations of the cohesin/Scc2 complex during chromosome loading.

bioRxiv · Dec 4, 2022Biochemistry

Sister chromatid cohesion establishment during DNA replication termination

G. Cameron, D. Gruszka, S. Xie, K. A. Nasmyth, M. Srinivasan, H. Yardimci

This study shows that sister chromatid cohesion is established during DNA replication termination by replisome-mediated pushing of pre-loaded cohesin complexes onto nascent DNA.

bioRxiv · Sep 15, 2022Biophysics

Formation of the clamped state by Scc2 and DNA overcomes the constraints imposed by zipping-up of the SMC coiled coils on cohesin's ATPase

M. Voulgaris, M. Srinivasan, K. A. Nasmyth

This study investigates how Scc2 and DNA clamping overcome coiled coil zipping-up constraints on cohesin's ATPase activity during loop extrusion.

bioRxiv · Jun 19, 2022 · PreprintBiochemistry

DNA passes through cohesin's hinge as well as its Smc3-kleisin interface

K. A. Nasmyth, J. E. Collier

This paper demonstrates that cohesin has two DNA gates, one at the Smc3/Scc1 interface and one at the Smc1/Smc3 hinge, with distinct regulatory requirements and functional roles in sister chromatid cohesion.

bioRxiv · May 30, 2022Biochemistry

ATP dependent DNA transport within cohesin: Scc2 clamps DNA on top of engaged heads while Scc3 promotes entrapment within the SMC-kleisin ring

J. E. Collier, B.-G. Lee, M. Brunet-Roig, S. Yatskevich, N. J. Petela, J. Metson, M. Voulgaris, A. Gonzalez Llamazares, J. Lowe, K. A. Nasmyth

The paper demonstrates that Scc2 clamps DNA in cohesin's E-S/E-K compartments while Scc3 facilitates DNA entrapment within the SMC-kleisin ring during DNA loop extrusion.

bioRxiv · Jun 3, 2020 · PreprintBiochemistry