M. Srinivasan

Metabolic cost for isometric force scales nonlinearlyand predicts how humans distribute forces across limbs

Sister chromatid cohesion establishment during DNA replication termination

This study shows that sister chromatid cohesion is established during DNA replication termination by replisome-mediated pushing of pre-loaded cohesin complexes onto nascent DNA.

A unified peptide array platform for antibody epitope binning, mapping, specificity and predictive off-target binding

This paper introduces a unified peptide array platform for high-resolution antibody epitope binning, mapping, and off-target binding prediction, demonstrating its application with anti-HER2 monoclonal antibodies.

Formation of the clamped state by Scc2 and DNA overcomes the constraints imposed by zipping-up of the SMC coiled coils on cohesin's ATPase

This study investigates how Scc2 and DNA clamping overcome coiled coil zipping-up constraints on cohesin's ATPase activity during loop extrusion.

Cryo-EM Structure of Bacterioferritin Nanocages Provides Insight into the Bio-mineralization of Ferritins

The paper reports cryo-EM structures of bacterioferritin nanocages and identifies residues involved in iron transport and biomineralization.

Pre-crastination: Time uncertainty increases walking effort

The paper examines how time constraints affect human walking speed, finding that people walk faster than their energy-optimal speed to account for time uncertainty.

Oral epithelial expression of angiotensin converting enzyme-2: Implications for COVID-19 diagnosis and prognosis.

The paper shows ACE-2 is abundantly expressed in oral epithelial cells, suggesting they may be entry sites for SARS-CoV-2 and that ACE-2 measurement in saliva could indicate early COVID-19 infection.

Differential Profiles of Soluble and Cellular Toll-like Receptors (TLRs) 2 and 4 in Chronic Periodontitis.

This study examines salivary soluble TLR-2/4 and epithelial cell-associated TLR-2/4 mRNA levels in periodontitis and gingivitis patients to assess their potential as diagnostic markers.