Author

H. Yardimci

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 5 Approach:experimental assay· 4 Approach:microscopy & imaging analysis· 2 Organism:bacteria (other)· 1 Assay:ChIP-seq· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

S. Xie· 3 shared D. R. Burnham· 2 shared D. T. Gruszka· 2 shared G. Cameron· 2 shared A. Ballandras-Colas· 1 shared A. N. Engelman· 1 shared A. Nans· 1 shared D. Gruszka· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

S. Xie

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Sister chromatid cohesion establishment during DNA replication termination

G. Cameron, D. Gruszka, S. Xie, K. A. Nasmyth, M. Srinivasan, H. Yardimci

This study shows that sister chromatid cohesion is established during DNA replication termination by replisome-mediated pushing of pre-loaded cohesin complexes onto nascent DNA.

bioRxiv · Sep 15, 2022Biophysics

Molecular determinants of the Bacillus subtilis chromosome origin basal unwinding system

S. Pelliciari, D. R. Burnham, G. Merces, H. Yardimci, H. Murray

This study identifies the molecular mechanism by which Bacillus subtilis DnaA binds to ssDNA motifs (DnaA-trios) to promote DNA unwinding at the origin of replication.

bioRxiv · Mar 18, 2022 · PreprintMicrobiology

Multivalent interactions essential for lentiviral integrase function

A. Ballandras-Colas, V. Chivukula, D. T. Gruszka, Z. Shan, P. K. Singh, V. E. Pye, R. K. McLean, G. J. Bedwell, W. Li, A. Nans, N. J. Cook, H. J. Fadel, E. M. Poeschla, D. J. Griffiths, J. Vargas, , P. Cherepanov

This study reports cryo-EM structures of the lentiviral intasome and shows that multivalent interactions are essential for integrase function and virus infectivity.

bioRxiv · Jan 26, 2022Biochemistry

Mechanism of RPA-Facilitated Processive DNA Unwinding by the Eukaryotic CMG Helicase

H. B. Kose, S. Xie, G. Cameron, M. S. Strycharska, H. Yardimci

This study investigates how RPA enhances CMG helicase activity by preventing dsDNA engagement and facilitating processive DNA unwinding at the replication fork.

bioRxiv · Oct 7, 2019 · PreprintBiochemistry

Three-dimensional super-resolution fluorescence imaging of DNA

S. Yardimci, D. R. Burnham, S. Y. A. Terry, H. Yardimci

This paper develops a 3D super-resolution imaging method for DNA using BALM and optical astigmatism, demonstrating its application to single DNA molecules and metaphase chromosomes.

bioRxiv · Oct 7, 2019Biophysics

Single-molecule imaging reveals control of parental histone recycling by free histones during DNA replication

D. T. Gruszka, S. Xie, H. Kimura, H. Yardimci

The paper uses single-molecule imaging in Xenopus laevis egg extracts to show that most parental histones are evicted during DNA replication, with histone recycling and nucleosome sliding occurring less frequently.

bioRxiv · Oct 1, 2019Biophysics