Daptomycin resistance in Enterococcus faecium can be delayed by disruption of the LiaFSR stress response pathway
A. G. Prater, H. H. Mehta, K. Beabout, A. Supandy, W. R. Miller, T. T. Tran, C. A. Arias, Y. Shamoo
This study shows that disrupting the LiaFSR pathway in Enterococcus faecium delays daptomycin resistance development, suggesting potential for combinatorial therapy with a LiaFSR inhibitor.
bioRxiv · Jun 23, 2020Microbiology