Evolution of Enterococcus faecium to A Combination of Daptomycin and Fosfomycin Reveals Distinct and Diverse Adaptive Strategies
A. Supandy, H. H. Mehta, T. T. Tran, W. R. Miller, R. Zhang, L. Xu, C. A. Arias, Y. Shamoo
This study investigates how Enterococcus faecium develops resistance to a combination of daptomycin and fosfomycin, finding that resistance mechanisms are largely independent and that fosfomycin resistance involves changes in phosphoenolpyruvate flux.
bioRxiv · Dec 20, 2021 · PreprintEvolutionary Biology