A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial differentiation
J. Ostrop, R. Zwiggelaar, M. T. Pedersen, F. Gerbe, K. Bösl, H. T. Lindholm, A. Diez-Sanchez, N. Parmar, S. Radetzki, J. P. von Kries, P. Jay, K. B. Jensen, C. Arrowsmith, M. J. Oudhoff
This study develops a semi-automated intestinal organoid screening method to identify epigenetic regulators of epithelial differentiation, finding that inhibiting type I PRMTs enhances differentiation and blocks adenoma growth.
bioRxiv · Jul 23, 2020Cell Biology