Author

A. Mehrani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Assay:cryo-EM· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. M. Stagg· 3 shared C. M. Dunham· 2 shared E. D. Hoffer· 2 shared A. E. Jerse· 1 shared B. A. Barad· 1 shared D. Dey· 1 shared D. Grotjahn· 1 shared D. Hosangadi· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

S. M. Stagg

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection

S. Aiyer, P. R. Baldwin, S. M. Tan, Z. Shan, J. Oh, A. Mehrani, M. E. Bowman, G. Louie, D. O. Passos, S. Đorđevic-Marquardt, M. Mietzsch, J. A. Hull, S. Hoshika, B. A. Barad, D. Grotjahn, , D. Lyumkis

This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.

bioRxiv · Jul 14, 2023Biophysics

Ribosome rescue inhibitors clear Neisseria gonorrhoeae in vivo using a new mechanism

Z. D. Aron, A. Mehrani, E. D. Hoffer, K. L. Connolly, M. C. Torhan, J. N. Alumasa, P. Srinivas, M. Cabrera, D. Hosangadi, J. S. Barbor, S. C. Cardinale, S. M. Kwasny, L. R. Morin, M. M. Butler, T. J. Opperman, , K. C. Keiler

The paper describes the development of ribosome rescue inhibitors that clear drug-resistant Neisseria gonorrhoeae in vivo through a novel mechanism involving ribosomal conformational changes.

bioRxiv · Jun 4, 2020 · PreprintMicrobiology

Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition

M. Nosrati, D. Dey, A. Mehrani, S. E. Strassler, N. Zelinskaya, E. D. Hoffer, S. M. Stagg, C. M. Dunham, G. L. Conn

This study identifies functionally critical residues in RmtC that distinguish between 30S-binding affinity and 16S rRNA modification through structural and biochemical analysis.

bioRxiv · Oct 3, 2019Biochemistry

Throughput and Resolution with a Next Generation Direct Electron Detector

J. H. Mendez, A. Mehrani, P. S. Randolph, S. M. Stagg

This paper evaluates a new direct electron detector (DE64) for cryo-electron microscopy, showing that counting mode provides better reconstruction resolution per unit time despite lower throughput.

bioRxiv · May 3, 2019Biophysics