Author

K. C. Kent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:rat· 5 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:host-pathogen & immune response· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. Wang· 5 shared G. Urabe· 5 shared M. Zhang· 5 shared Y. Huang· 5 shared L. Guo· 3 shared J. Li· 2 shared L.-W. Guo· 2 shared A. Huttinger· 1 shared

Activity by Year

2019-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersPathology

B. Wang

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Author profile →

5 papers

Recent·Most cited

Partnership between epigenetic reader BRD4 and transcription factor CEBPD

Q. Wang, M. Zhang, G. Urabe, B. Wang, G. Ozer, Y. Huang, K. C. Kent, L. Guo

This study identifies a partnership between BRD4 and CEBPD that promotes inflammatory SMC state transition and CEBPD transcription in vascular disease.

bioRxiv · Mar 27, 2020 · PreprintCell Biology

The BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation

M. Zhang, B. Wang, G. Urabe, Y. Huang, J. Plutzky, K. C. Kent, L.-W. Guo

This study identifies the BD2 domain of BRD4 as critical for EndoMT and vein graft neointima formation, suggesting it as a therapeutic target.

Cellular Signalling · Sep 1, 2019Peer-reviewedPathology

Silencing epigenetic writer DOT1L attenuates intimal hyperplasia

Y. Huang, G. Urabe, M. Zhang, J. Li, B. Wang, K. C. Kent, L. Guo

This study shows that inhibiting DOT1L reduces intimal hyperplasia in rat carotid arteries by lowering H3K79 methylation levels.

bioRxiv · Aug 10, 2019Pathology

A non-canonical role and regulations of polo-like kinase-4 in fibroblast cell-type transition

J. Li, G. Urabe, M. Zhang, Y. Huang, B. Wang, L. Marcho, H. Shen, K. C. Kent, L.-W. Guo

This study identifies a non-canonical role for PLK4 in fibroblast cell-type transition and shows its regulation by BRD4 and PDGFR pathways, suggesting PLK4 inhibition as a potential anti-fibrotic intervention.

bioRxiv · Mar 31, 2019 · PreprintCell Biology

PERK inhibition mitigates restenosis and thrombosis - a potential low-thrombogenic anti-restenotic paradigm

B. Wang, M. Zhang, G. Urabe, G. Chen, D. Wheeler, D. Dornbos, A. Huttinger, Y. Huang, S. Nimjee, S. Gong, L. Guo, K. C. Kent

This study shows that PERK inhibition reduces restenosis and thrombosis in animal models, suggesting it as a potential therapeutic strategy for drug-eluting stents.

bioRxiv · Mar 18, 2019 · PreprintPathology