K. Choudhury

Modulation of pore opening of Eukaryotic sodium channels by π-helices in S6

This paper investigates how π-helices in S6 helices of eukaryotic sodium channels affect pore conductance, showing that their presence leads to fully conductive states while their absence results in sub-conductance or non-conducting states.

An α-π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb

The paper identifies an α-π helix transition in the S6 helix of NavAb that enables pore opening and contributes to the conformational cycle of the bacterial sodium channel.

Differential Binding Kinetics for Evaluating Immune Checkpoint Inhibitors in Serum

This study measures binding kinetics of immune checkpoint inhibitors in serum using GMR biosensors and compares them to label-free methods, finding serum affects off-rates and pharmacological modeling.

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing Asparagine

This paper uses molecular modeling and simulations to propose a stable open state model for the NavMs channel, featuring a π-helix and conserved asparagine residue, resolving disputes about its functional annotation.

Functional crosstalk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5

This paper investigates how phosphorylation and disease-causing mutations interact in Nav1.5, showing that mutations can amplify phosphorylation's impact on channel function and drug sensitivity.

Mechanism and effects of the skeletal muscle Nav1.4 inhibition by cannabidiol

This study investigates how cannabidiol inhibits Nav1.4 channels in skeletal muscle by modulating membrane elasticity and directly interacting with the channel pore.