K. Yamashita

This study reports six LAT1 structures bound with ligands, revealing substrate recognition and inhibition mechanisms, including the role of JPH203 as an anticancer drug.

The paper determines the cryo-EM structures of two K+-selective channelrhodopsins, revealing a unique mechanism for K+ selectivity distinct from canonical K+ channels.

This study shows that evofosfamide and gemcitabine work together in pancreatic cancer xenografts by improving tumor oxygenation and inhibiting DNA repair, with effects varying by tumor type.

The paper identifies Raf13 and IREH1 as growth-promoting kinases suppressed by PP2A under drought stress, modulating the growth-stress trade-off in Arabidopsis.

This study compares two spin probes for oxygen measurement in vivo, finding Ox071 more sensitive and capable of a broader pO2 range.

This study reveals the structure of the hyperstable S-layer in Deinococcus radiodurans, showing it is formed by immunoglobulin-like HPI proteins arranged in a hexagonal lattice.

The paper develops cell-free protein crystallization (CFPC) to produce high-quality protein nanocrystals for structure determination, achieving a 2.11 Å resolution structure for CipA.

The paper presents the cryo-EM structure of ChRmine, revealing unique architectural features and provides insights into its conduction mechanism and potential for optogenetic applications.

This study shows that electrical polarization of carbonate-substituted hydroxyapatite improves surface wettability, enhancing osteoclast-mediated resorption without affecting early osteoclast differentiation.

EMDA is a Python library for cryo-EM data analysis, focusing on validation tools like local correlation and map overlay.

This paper introduces Servalcat, a Python package for refining atomic models and calculating difference maps in cryo-EM single particle analysis.

This study investigates the interaction between DEPTOR and mTORC1, revealing DEPTOR as a partial inhibitor that is more effective against activated mTORC1, with mutual antagonism mediated by phosphorylation and structural interactions.

The paper identifies and crystallizes public TCRs from SARS-CoV-2-specific Tfh cells in COVID-19 patients, showing they recognize conserved spike epitopes and cross-react with symbiotic bacteria.

This study evaluates a plasmid DNA vaccine against SARS-CoV-2 using a pyro-drive jet injector, showing strong immune response and protection in rodents.

The paper investigates how epigenetic regulation loss leads to genetic fixation of novel traits in medaka fish through methylation profiling and CRISPR/Cas9 deletion.

The paper presents the crystal structure of a HeR mutant with an identical absorption spectrum to wild-type, revealing a unique spectral shift mechanism through counterion and serine cluster interactions.

This study shows that phosphorylation and dephosphorylation of PAR-3 at Ser852 and Ser889 regulate its clustering, localization, and function in cell polarity and junction formation.

This study presents the structural and functional analysis of Rh-PDE from Salpingoeca rosetta, revealing its photoactivation mechanism and expanding the definition of rhodopsins.

The paper reports cryo-EM structures of six intermediates in the ATP8A1-CDC50a flippase cycle, revealing the mechanism of phospholipid translocation.

This study evaluates the cardiovascular effects of colforsin in normal and acute respiratory acidosis canine models, finding it increases cardiac output and reduces systemic vascular resistance compared to baseline.

This study determines the crystal structures of TPT bound to substrates, revealing the molecular basis of its strict 1:1 exchange mechanism.