Author

J. M. Paggi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Assay:cryo-EM· 2 Approach:statistical model· 2 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

R. O. Dror· 4 shared C. Ramakrishnan· 2 shared E. F. X. Byrne· 2 shared H. E. Kato· 2 shared K. Deisseroth· 2 shared K. E. Kishi· 2 shared K. Inoue· 2 shared K. Yamashita· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiophysics

R. O. Dror

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4 papers

Recent·Most cited

Structural basis for ion selectivity in potassium-selective channelrhodopsins

S. Tajima, Y. S. Kim, M. Fukuda, E. F. X. Byrne, P. Y. Wang, J. M. Paggi, K. E. Kishi, C. Ramakrishnan, S. Takaramoto, T. Nagata, M. Konno, M. Sugiura, K. Katayama, T. E. Matsui, K. Yamashita, , H. E. Kato

The paper determines the cryo-EM structures of two K+-selective channelrhodopsins, revealing a unique mechanism for K+ selectivity distinct from canonical K+ channels.

bioRxiv · Oct 30, 2022Biophysics

Structural insights into distinct signaling profiles of the μOR activated by diverse agonists

Q. Qu, W. Huang, D. Aydin, J. M. Paggi, A. B. Seven, H. Wang, S. Chakraborty, T. Che, J. F. DiBerto, M. J. Robertson, A. Inoue, B. L. Roth, S. Majumdar, R. O. Dror, B. K. Kobilka, G. Skiniotis

This study compares the structural and signaling differences between two μOR agonists, lofentanil and mitragynine pseudoindoxyl, revealing how their distinct binding modes lead to different G protein and β-arrestin activation profiles.

bioRxiv · Dec 7, 2021 · PreprintBiophysics

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

K. E. Kishi, Y. S. Kim, M. Fukuda, T. Kusakizako, E. Thadhani, E. F. X. Byrne, J. M. Paggi, C. Ramakrishnan, T. E. Matsui, K. Yamashita, T. Nagata, M. Konno, P. Y. Wang, M. Inoue, T. Benster, , H. E. Kato

The paper presents the cryo-EM structure of ChRmine, revealing unique architectural features and provides insights into its conduction mechanism and potential for optogenetic applications.

bioRxiv · Aug 15, 2021Biophysics

Leveraging non-structural data to predict structures of protein-ligand complexes

J. M. Paggi, J. A. Belk, S. A. Hollingsworth, N. Villanueva, A. S. Powers, M. J. Clark, A. G. Chemparathy, J. E. Tynan, T. K. Lau, R. K. Sunahara, R. O. Dror

This paper presents a statistical framework combining physics-based and ligand-based methods to predict protein-ligand complex structures, improving pose prediction accuracy for drug targets.

bioRxiv · Jun 1, 2020 · PreprintBiophysics