Author

K. Donovan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Toker· 2 shared E. Erickson· 2 shared I. You· 2 shared A. Dugourd· 1 shared C. Crafter· 1 shared E. Fischer· 1 shared E. Leuthardt· 1 shared E. S. Fischer· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

A. Toker

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Does Vibrotactile Stimulation of the Auricular Vagus Nerve Enhance Working Memory? A Behavioral and Physiological Investigation

G. Tan, J. Adams, K. Donovan, P. Demarest, J. T. Willie, P. Brunner, E. Leuthardt

This study investigates whether vibrotactile taVNS improves working memory performance and arousal, finding significant improvements in performance and reduced arousal decline during high-cognitive-load tasks.

bioRxiv · Mar 24, 2024Bioengineering

Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

E. Erickson, I. You, G. Perry, A. Dugourd, K. Donovan, C. Crafter, J. Johannes, S. Williamson, J. Moss, S. Ros, R. Ziegler, S. Barry, E. Fischer, N. Gray, R. Madsen, A. Toker

This study develops a second-generation AKT degrader, INY-05-040, showing improved efficacy over existing inhibitors in breast cancer cells by inducing stress MAPK signaling.

bioRxiv · Oct 11, 2022 · PreprintCancer Biology

Discovery of an AKT Degrader with Prolonged Inhibition ofDownstream Signaling

I. You, E. Erickson, K. Donovan, N. Eleuteri, E. S. Fischer, N. S. Gray, A. Toker

This study develops INY-03-041, a pan-AKT degrader that shows prolonged inhibition of AKT and downstream signaling effects compared to traditional inhibitors.

bioRxiv · Nov 20, 2019Cancer Biology