J. Moss

ADP-ribose-acceptor hydrolase 2 (Arh2) deficiency results in cardiac dysfunction, tumorigenesis, inflammation, and decreased survival

This study shows that Arh2 deficiency leads to cardiac dysfunction, tumorigenesis, inflammation, and reduced survival in mice.

Macrodomain Mac1 of SARS-CoV-2 Nonstructural Protein 3 Hydrolyzes Diverse ADP-ribosylated Substrates

This study identifies SARS-CoV-2 Mac1's ability to hydrolyze specific ADP-ribosylated substrates, revealing its role in disrupting host ADP-ribosylation pathways and potential as a therapeutic target.

Mono-ADP-ribosyltransferase 1 (Artc1)-deficiency decreases tumorigenesis, increases inflammation, decreases cardiac contractility, and reduces survival

Loss of genital epithelial barrier function is greater with depot-medroxyprogesterone acetate than intravaginal rings that release etonogestrel and ethinyl estradiol

This study compares the effects of DMPA and NuvaRing on genital epithelial barrier function in rhesus macaques, finding greater compromise with DMPA.

Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

This study develops a second-generation AKT degrader, INY-05-040, showing improved efficacy over existing inhibitors in breast cancer cells by inducing stress MAPK signaling.

Development of methylation-based biomarkers for breast cancer detection by model training and validation in synthetic cell-free DNA

This study develops methylation-based biomarkers for breast cancer detection using synthetic cell-free DNA and validates their performance with in vitro testing.

ETV2 regulates PARP-1 binding protein to induce ER stress-mediated cell death in tuberin-deficient cells

This study identifies ETV2 as a regulator of cell death in Tsc2-deficient cells through PARPBP and ER stress, suggesting a potential therapeutic target for LAM.

FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role.

This study shows FKBP13 is upregulated in interstitial lung diseases and correlates with disease severity, suggesting a protective role against fibrosis.