Author

I. You

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Approach:deep learning· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

N. Gray· 3 shared A. Toker· 2 shared E. Erickson· 2 shared E. S. Fischer· 2 shared K. Donovan· 2 shared N. S. Gray· 2 shared A. Chakravarty· 1 shared A. Dugourd· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

N. Gray

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

Z. Li, H.-Y. Liu, Z. He, A. Chakravarty, R. P. Golden, Z. Jiang, I. You, H. Yue, K. A. Donovan, G. Du, J. Che, J. Tse, I. Che, W. Lu, E. S. Fischer, , P. L. Yang

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

Advanced Science · Aug 15, 2024Peer-reviewedBiochemistry

Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors

C. Chen, Y.-P. Jiang, I. You, N. Gray, R. Z. Lin

This study shows that down-regulating AKT proteins slows mutant-KRAS pancreatic tumor growth more effectively than inhibiting AKT kinase activity.

bioRxiv · May 3, 2024Cancer Biology

Targeted Kinase Degradation via the KLHDC2 Ubiquitin E3 Ligase

Y. Kim, C. Seo, E. Jeon, I. You, K. Hwang, N. Kim, H.-S. Choi, S. M. Hinshaw, T. Sim, N. Gray

This study demonstrates the use of KLHDC2 as a substrate adaptor for targeted protein degradation using peptide-based bivalent compounds.

bioRxiv · Dec 17, 2022Biochemistry

Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

E. Erickson, I. You, G. Perry, A. Dugourd, K. Donovan, C. Crafter, J. Johannes, S. Williamson, J. Moss, S. Ros, R. Ziegler, S. Barry, E. Fischer, N. Gray, R. Madsen, A. Toker

This study develops a second-generation AKT degrader, INY-05-040, showing improved efficacy over existing inhibitors in breast cancer cells by inducing stress MAPK signaling.

bioRxiv · Oct 11, 2022 · PreprintCancer Biology

Label-free bone marrow white blood cell classification using refractive index tomograms and deep learning

D. Ryu, J. Kim, D. Lim, H.-S. Min, I. You, D. Cho, Y. Park

This paper presents a label-free method for classifying bone marrow white blood cells using 3D refractive index tomograms and deep learning, achieving high accuracy in subtype classification.

bioRxiv · Nov 13, 2020Bioengineering

Discovery of an AKT Degrader with Prolonged Inhibition ofDownstream Signaling

I. You, E. Erickson, K. Donovan, N. Eleuteri, E. S. Fischer, N. S. Gray, A. Toker

This study develops INY-03-041, a pan-AKT degrader that shows prolonged inhibition of AKT and downstream signaling effects compared to traditional inhibitors.

bioRxiv · Nov 20, 2019Cancer Biology