Author

R. Madsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Dugourd· 1 shared A. Toker· 1 shared B. Mahler-Araujo· 1 shared B. Vanhaesebroeck· 1 shared C. Crafter· 1 shared E. Erickson· 1 shared E. Fischer· 1 shared G. Perry· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Dugourd

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

E. Erickson, I. You, G. Perry, A. Dugourd, K. Donovan, C. Crafter, J. Johannes, S. Williamson, J. Moss, S. Ros, R. Ziegler, S. Barry, E. Fischer, N. Gray, R. Madsen, A. Toker

This study develops a second-generation AKT degrader, INY-05-040, showing improved efficacy over existing inhibitors in breast cancer cells by inducing stress MAPK signaling.

bioRxiv · Oct 11, 2022 · PreprintCancer Biology

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner

R. Madsen, R. Knox, W. Pearce, S. Lopez, B. Mahler-Araujo, N. McGranahan, B. Vanhaesebroeck, R. Semple

This study shows that homozygous PIK3CAH1047R mutations in iPSCs lead to cancer-like changes, while heterozygous mutations do not, highlighting allele dose-dependent effects.

bioRxiv · Dec 13, 2018Cancer Biology