A. Dugourd

A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens

The paper introduces a single-sample workflow, MTBE-SP3, for simultaneous proteomic and metabolomic analysis, showing it reduces technical variation and enables consistent results across biological matrices.

Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

This study develops a second-generation AKT degrader, INY-05-040, showing improved efficacy over existing inhibitors in breast cancer cells by inducing stress MAPK signaling.

Deep Phosphoproteomic Elucidation of Metformin-Signaling in Heterogenous Colorectal Cancer Cells

This study uses phosphoproteomics to analyze metformin signaling in CRC cell lines, revealing heterogeneous responses and identifying potential drug interactions.

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis

This study evaluates pre-analytical factors affecting plasma and serum proteome and metabolome stability, recommending standardized protocols for clinical use.

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

Increasing triacylglycerol formation and lipid storage by unsaturated lipids protects renal proximal tubules in diabetes

This study shows that unsaturated lipids reduce renal damage in diabetes by increasing lipid storage and protecting against ER stress in proximal tubular cells.

Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival

The paper analyzes protein activity changes in cancer using genomics and proteomics data to identify drivers of signaling dysregulation and their impact on patient survival.