Author

K. E. Healy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Organism:human· 4 Assay:electrophysiology· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Tveito· 3 shared B. Charrez· 3 shared S. Wall· 3 shared V. Charwat· 3 shared K. H. Jaeger· 2 shared N. Huebsch· 2 shared A. Edwards· 1 shared A. G. Edwards· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiophysics

A. Tveito

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Author profile →

4 papers

Recent·Most cited

Do calcium channel blockers applied to cardiomyocytes cause increased channel expression resulting in reduced efficacy?

K. H. Jaeger, V. Charwat, S. Wall, K. E. Healy, A. Tveito

The paper investigates whether calcium channel blockers like nifedipine reduce efficacy in cardiomyocytes by inducing increased calcium channel expression due to intracellular calcium level changes.

bioRxiv · Oct 9, 2023Biophysics

Isochoric supercooled preservation and revival of human cardiac microtissues

M. J. Powell-Palm, V. Charwat, B. Charrez, B. A. Siemons, K. E. Healy, B. Rubinsky

This study demonstrates isochoric supercooling for sub-zero preservation and revival of human cardiac microtissues without chemical cryoprotectants, maintaining functional and structural integrity.

bioRxiv · Mar 22, 2021Bioengineering

Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip

N. Huebsch, B. Charrez, B. Siemons, S. C. Boggess, S. Wall, G. Neiman, V. Charwat, K. Jaeger, F. L. T. Montiel, N. C. Jeffreys, N. Deveshwar, A. Edwards, J. Serrano, M. Snuderl, A. Stahl, , K. E. Healy

This study improves electrophysiological maturation of hiPSC-derived cardiomyocytes by combining metabolic cues and biophysical stimuli, revealing genotype-dependent responses to maturation media.

bioRxiv · Nov 14, 2020Bioengineering

Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems

A. Tveito, K. H. Jaeger, N. Huebsch, B. Charrez, A. G. Edwards, S. Wall, K. E. Healy

This paper develops a computational framework to predict drug effects in mature cardiomyocytes using data from immature human stem cell-derived cardiomyocytes in microphysiological systems.

bioRxiv · Jul 10, 2018Biophysics