Author

B. Charrez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 6 Organism:human· 6 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:electrophysiology· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

V. Charwat· 4 shared A. Tveito· 3 shared K. E. Healy· 3 shared S. Wall· 3 shared A. Edwards· 2 shared B. Siemons· 2 shared H. Finsberg· 2 shared K. H. Jaeger· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersBioengineering

V. Charwat

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

M. M. Sperry, B. Charrez, H. Fotowat, E. Gardner, K. Pilobello, Z. Izadifar, T. Lin, A. Kuelker, S. Kaki, M. Lewandowski, S. Lightbown, R. Martinez, S. Marquez, J. Moore, M. Plaza-Oliver, , D. E. Ingber

The paper identifies SNC80 as a drug that reversibly slows metabolism in Xenopus and demonstrates its cross-species applicability in human organs-on-chips and porcine organs.

eLife · Sep 24, 2024Peer-reviewedBioengineering

Isochoric supercooled preservation and revival of human cardiac microtissues

M. J. Powell-Palm, V. Charwat, B. Charrez, B. A. Siemons, K. E. Healy, B. Rubinsky

This study demonstrates isochoric supercooling for sub-zero preservation and revival of human cardiac microtissues without chemical cryoprotectants, maintaining functional and structural integrity.

bioRxiv · Mar 22, 2021Bioengineering

In Vitro Safety "Clinical Trial" of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy

B. Charrez, V. Charwat, B. Siemons, H. Finsberg, A. Edwards, E. Miller, K. Healy

This paper uses a cardiac microphysiological system to assess the cardiotoxicity of hydroxychloroquine and azithromycin polytherapy, finding increased QT interval and reduced arrhythmias compared to monotherapy.

bioRxiv · Dec 21, 2020 · PreprintBioengineering

Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip

N. Huebsch, B. Charrez, B. Siemons, S. C. Boggess, S. Wall, G. Neiman, V. Charwat, K. Jaeger, F. L. T. Montiel, N. C. Jeffreys, N. Deveshwar, A. Edwards, J. Serrano, M. Snuderl, A. Stahl, , K. E. Healy

This study improves electrophysiological maturation of hiPSC-derived cardiomyocytes by combining metabolic cues and biophysical stimuli, revealing genotype-dependent responses to maturation media.

bioRxiv · Nov 14, 2020Bioengineering

Improved computational identification of drug response using optical measurements of human stem cell derived cardiomyocytes in microphysiological systems

K. H. Jaeger, V. Charwat, B. Charrez, H. Finsberg, M. M. Maleckar, S. Wall, K. Healy, A. Tveito

The paper improves computational methods to identify drug responses in mature human stem cell-derived cardiomyocytes using optical measurements and mathematical modeling.

bioRxiv · Oct 1, 2019Biophysics

Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems

A. Tveito, K. H. Jaeger, N. Huebsch, B. Charrez, A. G. Edwards, S. Wall, K. E. Healy

This paper develops a computational framework to predict drug effects in mature cardiomyocytes using data from immature human stem cell-derived cardiomyocytes in microphysiological systems.

bioRxiv · Jul 10, 2018Biophysics