V. Charwat

Do calcium channel blockers applied to cardiomyocytes cause increased channel expression resulting in reduced efficacy?

The paper investigates whether calcium channel blockers like nifedipine reduce efficacy in cardiomyocytes by inducing increased calcium channel expression due to intracellular calcium level changes.

Isochoric supercooled preservation and revival of human cardiac microtissues

This study demonstrates isochoric supercooling for sub-zero preservation and revival of human cardiac microtissues without chemical cryoprotectants, maintaining functional and structural integrity.

In Vitro Safety "Clinical Trial" of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy

This paper uses a cardiac microphysiological system to assess the cardiotoxicity of hydroxychloroquine and azithromycin polytherapy, finding increased QT interval and reduced arrhythmias compared to monotherapy.

Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip

This study improves electrophysiological maturation of hiPSC-derived cardiomyocytes by combining metabolic cues and biophysical stimuli, revealing genotype-dependent responses to maturation media.

Identifying drug response by combining measurements of the membrane potential, the cytosolic calcium concentration, and the extracellular potential in microphysiological systems

The paper combines membrane potential, cytosolic calcium, and extracellular potential measurements to accurately estimate sodium channel current density and drug effects in hiPSC-CMs.

Integrated hiPSC-based liver and heart microphysiological systems predict unsafe drug-drug interaction

The paper integrates hiPSC-based liver and heart microphysiological systems to predict drug-drug interactions, showing ketoconazole inhibits cisapride metabolism, causing arrhythmia in cardiac MPSs.

Improved computational identification of drug response using optical measurements of human stem cell derived cardiomyocytes in microphysiological systems

The paper improves computational methods to identify drug responses in mature human stem cell-derived cardiomyocytes using optical measurements and mathematical modeling.

From 3D to 3D: isolation of mesenchymal stem/stromal cells into a three-dimensional human platelet lysate matrix

This study develops a method to isolate mesenchymal stem/stromal cells directly into a 3D hydrogel matrix, showing similar phenotype and differentiation capacity compared to traditional 2D methods.