K. H. Jaeger

A possible path to persistent re-entry waves at the outlet of the left pulmonary vein

The paper models how calcium current reduction in cardiomyocytes at the left pulmonary vein outlet can lead to persistent re-entry waves, contributing to atrial fibrillation progression.

Evaluating computational efforts and physiological resolution of mathematical models of cardiac tissue

The paper evaluates five mathematical models of cardiac tissue to assess their computational efficiency and physiological accuracy for different tissue sizes and resolutions.

Do calcium channel blockers applied to cardiomyocytes cause increased channel expression resulting in reduced efficacy?

The paper investigates whether calcium channel blockers like nifedipine reduce efficacy in cardiomyocytes by inducing increased calcium channel expression due to intracellular calcium level changes.

Nano-scale solution of the Poisson-Nernst-Planck (PNP) equations in a fraction of two neighboring cells reveals the magnitude of intercellular electrochemical waves

The paper solves the Poisson-Nernst-Planck equations at the nano-scale between two neighboring cells to demonstrate how electrochemical waves can propagate through intercellular spaces.

Mutations change excitability and the probability of re-entry in a computational model of cardiac myocytes in the sleeve of the pulmonary vein

The paper uses a computational model to study how AF-associated mutations affect ectopic beats and re-entry in the pulmonary vein-left atrium transition region.

Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes

The paper develops a computational method to predict adult drug responses from in vitro measurements of patient-derived stem cell cardiomyocytes in short QT syndrome.

Identifying drug response by combining measurements of the membrane potential, the cytosolic calcium concentration, and the extracellular potential in microphysiological systems

The paper combines membrane potential, cytosolic calcium, and extracellular potential measurements to accurately estimate sodium channel current density and drug effects in hiPSC-CMs.

Improved computational identification of drug response using optical measurements of human stem cell derived cardiomyocytes in microphysiological systems

The paper improves computational methods to identify drug responses in mature human stem cell-derived cardiomyocytes using optical measurements and mathematical modeling.

Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems

This paper develops a computational framework to predict drug effects in mature cardiomyocytes using data from immature human stem cell-derived cardiomyocytes in microphysiological systems.