Author

K. Gretarsson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Lu· 3 shared E. Nudler· 2 shared K.-J. Armache· 2 shared P. De Ioannes· 2 shared R. Lee· 2 shared S. Abini-Agbomson· 2 shared A. D. Viny· 1 shared A. Molotkov· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

C. Lu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Combined Mek inhibition and Pparg activation Eradicates Muscle Invasive Bladder cancer in a Mouse Model of BBN-induced Carcinogenesis

T. Tate, S. A. Plumber, H. Al-Ahmadie, X. Chen, W. Choi, C. Lu, A. D. Viny, E. Batourina, K. Gretarsson, B. Alija, A. Molotkov, G. Wiessner, J. M. Mckiernan, D. J. McConkey, C. Dinney, , C. L. Mendelsohn

This study shows that combining MEK inhibition and Pparg activation eradicates muscle-invasive bladder cancer in a mouse model by reversing tumor differentiation and inducing apoptosis.

bioRxiv · Aug 19, 2023 · PreprintCancer Biology

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

S. Abini-Agbomson, K. Gretarsson, R. M. Shih, L. Hsieh, T. Lou, P. De Ioannes, N. Vasilyev, R. Lee, M. Wang, M. Simon, J.-P. Armache, E. Nudler, G. Narlikar, S. Liu, C. Lu, K.-J. Armache

This study characterizes the catalytic and non-catalytic mechanisms of SUV420H1 by determining cryo-EM structures and showing its role in DNA accessibility and chromatin condensation.

bioRxiv · Mar 17, 2023Biochemistry

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1

J. F. Thomas, M. I. Valencia-Sanchez, S. Tamburri, S. L. Gloor, S. Rustichelli, V. Godinez-Lopez, P. De Ioannes, R. Lee, S. Abini-Agbomson, K. Gretarsson, J. M. Burg, A. R. Hickman, L. Sun, S. Gopinath, H. Taylor, , K.-J. Armache

This study reveals the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1 and explains how cancer mutations disrupt this process.

bioRxiv · Feb 23, 2023Biochemistry