Author

A. D. Viny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

R. L. Bowman· 2 shared R. L. Levine· 2 shared A. D. Goldberg· 1 shared A. Molotkov· 1 shared A. Navitski· 1 shared A. Ooi· 1 shared A. ZEHIR· 1 shared B. Alija· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

R. L. Bowman

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Author profile →

4 papers

Recent·Most cited

Mediator Subunit Med4 Enforces Metastatic Dormancy in Breast Cancer

S.-Y. Bae, H.-H. Ling, Y. Chen, H. Chen, D. Kumar, J. Zhang, A. D. Viny, R. A. DePinho, F. G. Giancotti

This study identifies Med4 as a regulator of metastatic dormancy in breast cancer, showing its role in maintaining chromatin structure and suppressing enhancer activation.

bioRxiv · Nov 18, 2023Cancer Biology

Combined Mek inhibition and Pparg activation Eradicates Muscle Invasive Bladder cancer in a Mouse Model of BBN-induced Carcinogenesis

T. Tate, S. A. Plumber, H. Al-Ahmadie, X. Chen, W. Choi, C. Lu, A. D. Viny, E. Batourina, K. Gretarsson, B. Alija, A. Molotkov, G. Wiessner, J. M. Mckiernan, D. J. McConkey, C. Dinney, , C. L. Mendelsohn

This study shows that combining MEK inhibition and Pparg activation eradicates muscle-invasive bladder cancer in a mouse model by reversing tumor differentiation and inducing apoptosis.

bioRxiv · Aug 19, 2023 · PreprintCancer Biology

Single cell mutational profiling delineates clonal trajectories in myeloid malignancies

L. A. Miles, R. L. Bowman, T. R. Merlinsky, I. S. Csete, A. Ooi, R. Durruthy-Durruthy, M. Bowman, C. Famulare, M. A. Patel, P. Mendez, C. Ainali, M. Manivannan, S. Sahu, A. D. Goldberg, K. Bolton, , R. L. Levine

This study uses single-cell mutational profiling to analyze clonal trajectories in myeloid malignancies, revealing patterns of mutation acquisition and clonal complexity.

bioRxiv · Feb 7, 2020 · PreprintCancer Biology

Stag1 and Stag2 regulate cell fate decisions in hematopoiesis through non-redundant topological control

A. D. Viny, R. L. Bowman, Y. Liu, V.-P. Lavallee, S. E. Redlich, W. Xiao, B. H. Durham, A. Navitski, J. Park, S. Braunstein, E. Azizi, M. Witkin, T. Baslan, C. J. Ott, D. Pe'er, , R. L. Levine

The paper shows Stag2 loss in HSPCs impairs B-cell lineage commitment by reducing chromatin accessibility, while Stag1 cannot restore this function despite rescuing topological domains.

bioRxiv · Mar 18, 2019 · PreprintCell Biology