Author

S. Gopinath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Organism:mouse· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. H. Uribe· 1 shared A. Iwasaki· 1 shared A. L. Goodman· 1 shared A. Larkin· 1 shared A. R. Hickman· 1 shared B. Cong· 1 shared C. A. Webber· 1 shared C. Kim· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 4 mutual co-author links

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1 shared paperCancer Biology

A. H. Uribe

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Vaginal lactobacilli produce anti-inflammatory beta-carboline compounds.

C. A. Webber, V. J. Glick, M. Martin, C. Kim, M. Ahmad, L. E. Simmons, S. Bang, M. C. Chao, N. C. Howard, S. M. Fortune, L. K. Beura, S. Y. Lee, J. Clardy, K. H. Kim, S. Gopinath

This study identifies beta-carboline compounds produced by vaginal lactobacilli that reduce inflammation by suppressing immune signaling pathways and demonstrate therapeutic potential in a mouse model.

bioRxiv · Feb 19, 2024 · PreprintMicrobiology

Colon Cancer Cells Evade Drug Action by Enhancing Drug Metabolism

B. Cong, T. Thakur, A. H. Uribe, E. Stamou, S. Gopinath, O. Maddocks, R. Cagan

The paper identifies glucuronidation pathway upregulation as a mechanism by which colon cancer cells develop resistance to trametinib, showing that inhibiting this pathway can reverse resistance in both Drosophila and mouse models.

bioRxiv · Dec 21, 2023Cancer Biology

Epithelial organoid supports resident memory CD8 T cell differentiation

M. Ulibarri, Y. Lin, J. R. Ramprashad, G. Han, M. H. Hasan, F. J. Mithila, C. Ma, S. Gopinath, N. Zhang, J. J. Milner, L. Beura

This paper develops a murine vaginal epithelial organoid system that supports CD8 T cell differentiation into resident memory T cells in vitro, showing phenotypic and transcriptional similarity to in vivo TRM.

bioRxiv · Dec 1, 2023Immunology

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1

J. F. Thomas, M. I. Valencia-Sanchez, S. Tamburri, S. L. Gloor, S. Rustichelli, V. Godinez-Lopez, P. De Ioannes, R. Lee, S. Abini-Agbomson, K. Gretarsson, J. M. Burg, A. R. Hickman, L. Sun, S. Gopinath, H. Taylor, , K.-J. Armache

This study reveals the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1 and explains how cancer mutations disrupt this process.

bioRxiv · Feb 23, 2023Biochemistry

An auto-inhibitory mechanism regulates the non-enzymatic functions of a histone demethylase

G. Raiymbek, S. An, N. Khurana, S. Gopinath, S. Biswas, A. Larkin, R. Trievel, U.-s. Cho, K. Ragunathan

The paper shows Epe1 regulates epigenetic inheritance through non-enzymatic interactions with Swi6HP1 and Clr3, independent of its catalytic activity.

bioRxiv · Jun 28, 2019 · PreprintBiochemistry

Microbiota-independent antiviral protection conferred by aminoglycoside antibiotics

S. Gopinath, M. V. Kim, T. Rakib, P. W. Wong, M. van Zandt, N. A. Barry, T. Kaisho, A. L. Goodman, A. Iwasaki

This study shows aminoglycoside antibiotics provide broad antiviral protection in vivo, independent of microbiota, by inducing interferon-stimulated genes via TLR3 and XCR1+ dendritic cells.

bioRxiv · Jan 16, 2018Immunology