BET inhibitors synergize with anti-PD1 by rescuing TCF1+ progenitor exhausted CD8+ T cells in Acute Myeloid Leukemia
K. A. Romine, H. J. Cho, Y. Kosaka, K. H. Byrd, J. L. Coy, P. A. Flynn, M. T. Newman, C. Loo, J. Scott, E. F. Lind
This study shows BET inhibitors enhance anti-PD1 therapy by reversing T cell exhaustion in AML, increasing CD8+ T cell function and reducing leukemia cells.
bioRxiv · Aug 4, 2021 · PreprintCancer Biology