Author

K. J. Metzner

University Hospital Zurich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. L. Braun· 2 shared E. Bernasconi· 2 shared H. Furrer· 2 shared H. H. Hirsch· 2 shared K. Neumann· 2 shared M. Cavassini· 2 shared M. Hoffmann· 2 shared the Swiss HIV Cohort Study· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersImmunology

D. L. Braun

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Targeting HIV-1 with CRISPR/Cas9 delivered by retargeted adenoviruses effectively suppresses viral replication

S. Klinnert, P. C. Freitag, A. Plueckthun, K. J. Metzner

This study combines CRISPR/Cas9 with retargeted adenoviruses to suppress HIV-1 replication in primary CD4+ T cells.

bioRxiv · Dec 18, 2023 · PreprintMicrobiology

Mycobacterium tuberculosis infection associated immune perturbations correlate with antiretroviral immunity

B. Tepekule Mueller, L. Joerimann, C. D. Schenkel, L. Opitz, J. Tschumi, R. Wolfensberger, K. Neumann, K. Kusejko, M. Zeeb, L. Boeck, M. Kaelin, J. Notter, H. Furrer, M. Hoffmann, H. H. Hirsch, , the Swiss HIV Cohort Study

The paper shows MTB infection in HIV-positive individuals correlates with immune system shifts and reduced HIV-1 viral load.

bioRxiv · Jul 14, 2023Immunology

Increased CHIP Prevalence Amongst People Living with HIV

Alexander G. Bick, Konstantin Popadin, Christian W. Thorball, Md Mesbah Uddin, Markella V. Zanni, Bing Yu, Matthias Cavassini, Andri Rauch, Philip Tarr, Patrick Schmid, Enos Bernasconi, Huldrych F. Günthard, Peter Libby, Eric Boerwinkle, Paul J. McLaren, , S. Yerly

The paper investigates the prevalence of clonal hematopoiesis of indeterminate potential (CHIP) in people living with HIV and finds a higher prevalence compared to controls.

Scientific Reports · Jan 12, 2022Peer-reviewedGenetic & Genomic Medicine

HIV-1 promoter is gradually silenced when integrated into BACH2

A. Inderbitzin, Y. L. Kok, L. Jörimann, A. Kelley, K. Neumann, D. Heinzer, T. Cathomen, K. J. Metzner

This study shows that HIV-1 promoters integrated into BACH2 are gradually silenced over time in Jurkat T-cells, without affecting BACH2 expression, potentially contributing to HIV-1 persistence.

PeerJ · Nov 24, 2020Peer-reviewedMicrobiology

Convergent evolution as an indicator for selection during acute HIV-1 infection

F. Bertels, K. J. Metzner, R. R. Regoes

The paper examines convergent mutations in HIV-1 env genes during early infection, finding an excess of convergent mutations indicating positive selection and purifying selection on private mutations.

bioRxiv · Nov 20, 2018Evolutionary Biology