Author

A. Plueckthun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Biophysics· 2 Cell Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:human· 6 Research Focus:drug response / drug discovery· 4 Organism:mouse· 3 Assay:protein structure· 3 Research Focus:protein structure prediction· 3 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

B. Dreier· 3 shared J. V. Schaefer· 3 shared P. C. Freitag· 3 shared J. Ehrenmann· 2 shared K. P. Hartmann· 2 shared Y. Waltenspuehl· 2 shared A. Kashyap· 1 shared A. Kipar· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersBiochemistry

B. Dreier

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Dendritic cell targeting in lymph nodes with engineered modular adapters improves HAdV5 and HC-HAdV5 tumor vaccination by co-secretion of IL-2v and IL-21

F. Weiss, J. Kolibius, P. C. Freitag, F. Gantenbein, A. Kipar, A. Plueckthun

This paper develops a modular adapter system to target dendritic cells with adenoviral vectors, enhancing tumor vaccination by improving DC transduction and co-delivering cytokines.

bioRxiv · Apr 27, 2024 · PreprintBiochemistry

Targeting HIV-1 with CRISPR/Cas9 delivered by retargeted adenoviruses effectively suppresses viral replication

S. Klinnert, P. C. Freitag, A. Plueckthun, K. J. Metzner

This study combines CRISPR/Cas9 with retargeted adenoviruses to suppress HIV-1 replication in primary CD4+ T cells.

bioRxiv · Dec 18, 2023 · PreprintMicrobiology

Side-Chain Dynamics of the α1B-Adrenergic Receptor determined by NMR via Methyl Relaxation

C. Baumann, W.-C. Chiang, R. Valsecchi, S. Jurt, M. Deluigi, M. Schuster, A. Plueckthun, O. Zerbe

This study uses NMR methyl relaxation to analyze side-chain dynamics of the α1B-adrenergic receptor, revealing differences in flexibility between orthosteric and allosteric ligand-bound states.

bioRxiv · May 9, 2023Biophysics

Designed Ankyrin Repeat Proteins for detecting prostate-specific antigen expression in vivo

M. Gut, B. Dreier, S. Furler, J. Sobek, A. Plueckthun, J. P. Holland

This paper develops PSA-specific DARPins for in vivo imaging to monitor drug resistance in prostate cancer.

bioRxiv · Jan 24, 2023 · PreprintBiochemistry

FAP-retargeted Ad5 enables in vivo gene delivery to stromal cells in the tumor microenvironment

K. P. Hartmann, M. van Gogh, P. C. Freitag, F. Kast, G. Nagy-Davidescu, L. Borsig, A. Plueckthun

This study develops a FAP-targeted adenovirus for delivering therapeutics to cancer-associated fibroblasts, showing reduced tumor growth in vivo.

bioRxiv · Dec 19, 2022 · PreprintBiochemistry

Nuclear myosin VI maintains replication fork stability

J. Shi, K. Hauschulte, I. Mikicic, S. Maharjan, V. Arz, J. B. Heidelberger, J. V. Schaefer, B. Dreier, A. Plueckthun, P. Beli, H. D. Ulrich, H.-P. Wollscheid

This study shows that nuclear myosin VI stabilizes stalled or reversed replication forks by interacting with WRNIP1 to prevent DNA2-mediated degradation during replication stress.

bioRxiv · Jul 28, 2022Cell Biology

Biofunctional nanodot arrays in living cells uncover synergistic co-condensation of Wnt signalodroplets

M. Philippi, C. P. Richter, M. Kappen, I. Watrinet, Y. Miao, M. Runge, L. Jorde, S. Korneev, M. Holtmannspoetter, R. Kurre, J. Holthuis, K. C. Garcia, A. Plueckthun, M. Steinhart, J. Piehler, C. You

The paper develops biofunctional nanodot arrays to study Wnt signalodroplets in live cells, revealing synergistic co-condensation through liquid-liquid phase separation.

bioRxiv · Jun 11, 2022Biophysics

Structural basis for the activation and ligand recognition of the human oxytocin receptor

Y. Waltenspuehl, J. Ehrenmann, S. Vacca, C. Thom, O. Medalia, A. Plueckthun

This study determines the cryo-EM structure of the oxytocin receptor bound to oxytocin, revealing its activation mechanism and ligand recognition.

bioRxiv · Feb 21, 2022Biochemistry

Structural basis of adenylyl cyclase 9 activation

C. Qi, P. Lavriha, V. Mehta, B. Khanppnavar, I. Mohammed, Y. Li, M. Lazaratos, J. V. Schaefer, B. Dreier, A. Plueckthun, A.-N. Bondar, C. W. Dessauer, V. M. Korkhov

The paper presents cryo-EM structures of AC9 in different states to reveal activator-induced conformational changes essential for its activation.

bioRxiv · Aug 11, 2021Biochemistry

Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells

N. Kirchhammer, M. P. Trefny, M. Natoli, D. Bruecher, S. N. Smith, F. Werner, V. Koch, D. Schreiner, E. Bartoszek, M. Buchi, M. Schmid, D. Breu, K. P. Hartmann, P. Zaytseva, D. S. Thommen, , A. Zippelius

The paper shows that CCL5-producing tissue-resident NK cells are critical for IL-12-mediated anti-tumor immunity and that CCL5 delivery can overcome resistance in tumors with low trNK cell infiltration.

bioRxiv · May 27, 2021 · PreprintImmunology

Crystal structure of the human oxytocin receptor

Y. Waltenspuehl, J. Schoeppe, J. Ehrenmann, L. Kummer, A. Plueckthun

The paper reports the crystal structure of the human oxytocin receptor complexed with retosiban, revealing insights into antagonist interactions and a Mg2+ coordination site.

bioRxiv · Feb 21, 2020Biochemistry

DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations

M. A. Vigano, D. Bieli, J. V. Schaefer, R. P. Jakob, S. Matsuda, T. Maier, A. Plueckthun, M. Affolter

This paper generates DARPins targeting mTFP1 and uses them to delocalize Rab proteins in cultured cells, demonstrating potential for direct protein manipulation in vivo.

bioRxiv · Jun 22, 2018Cell Biology