Peter Libby

Selective PPAR-α activation with pemafibrate attenuates macrophage-mediated progression of calcific aortic valve disease

This study shows pemafibrate reduces calcific aortic valve disease by modulating macrophage-VIC interactions, independent of lipid lowering.

Human Plasma Proteomic Profile of Clonal Hematopoiesis

The paper identifies plasma proteins associated with clonal hematopoiesis and links them to cardiovascular disease through proteomic and genetic analyses.

Multitargeted Reduction of Inflammation and Atherosclerosis in Tet2-deficient CHIP via XPO1 Inhibition and Atf3 restoration

Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis

This study analyzes 4,187 participants over 21 years to identify factors influencing the development of clonal hematopoiesis, finding age, sex, and dyslipidemia as significant predictors.

Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular risk

The paper identifies IL1RAP and AIM2 as key modifiers of CHIP-associated cardiovascular risk using UK Biobank data and CRISPR experiments in mice.

Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways

This study identifies shared immune pathways between coronary artery disease and pneumonia through genome-wide pleiotropy analysis, highlighting ADAMTS7 and IL6R as key genes with opposing effects on the two conditions.

Increased CHIP Prevalence Amongst People Living with HIV

The paper investigates the prevalence of clonal hematopoiesis of indeterminate potential (CHIP) in people living with HIV and finds a higher prevalence compared to controls.

TP53-mediated clonal hematopoiesis confers increased risk for incident peripheral artery disease

This study shows that clonal hematopoiesis, especially with DDR gene mutations, increases the risk of peripheral artery disease and atherosclerosis.