Author

K. John McLaughlin

Nationwide Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Benedict S. KhooiD· 1 shared Mehmet Emir YALVAÇiD· 1 shared Nancy RatneriD· 1 shared Robert F. HenniganiD· 1 shared Sigrid EckardtiD· 1 shared Syed-Rehan A. HussainiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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1 shared paperMolecular Biology

Benedict S. KhooORCID

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2 papers

Recent·Most cited

Active Merlin Binds RalB to Regulate Exocytosis

Robert F. Hennigan, K. John McLaughlin, Nancy Ratner

This study identifies RalB as a novel binding partner for active Merlin and shows its role in regulating exocytosis through the RalA/B pathway, suggesting therapeutic potential for NF2-related schwannoma.

bioRxiv · Jun 13, 2025 · PreprintCancer Biology

Adapting CRISPR/Cas9 System for Targeting Mitochondrial Genome

Syed-Rehan A. Hussain, Mehmet Emir YALVAÇ, Benedict S. Khoo, Sigrid Eckardt, K. John McLaughlin

This study demonstrates a method to edit mitochondrial DNA using CRISPR-Cas9 by modifying guide RNA with a stem loop element for mitochondrial targeting.

Frontiers in Genetics · Apr 6, 2021Peer-reviewedMolecular Biology