Mechanisms Generating Cancer Genome Complexity From A Single Cell Division Error
N. Umbreit, C.-Z. Zhang, L. D. Lynch, L. J. Blaine, A. M. Cheng, R. W. Tourdot, L. Sun, H. F. Almubarak, K. Judge, T. J. Mitchell, A. Spektor, D. Pellman
This study identifies a mutational cascade triggered by chromosome bridge formation that leads to chromothripsis and contributes to cancer genome complexity and sub-clonal heterogeneity.
bioRxiv · Nov 7, 2019Cancer Biology