Author

R. W. Tourdot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

Frequent Co-Authors

C.-Z. Zhang· 2 shared A. F. Long· 1 shared A. M. Cheng· 1 shared A. M. Leidal· 1 shared A. P. Wiita· 1 shared A. Sadagopan· 1 shared A. Spektor· 1 shared C. Bao· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

C.-Z. Zhang

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Author profile →

3 papers

Recent·Most cited

A genetic basis for cancer sex differences revealed in Xp11 translocation renal cell carcinoma

M. Achom, A. Sadagopan, C. Bao, F. McBride, Q. Xu, P. Konda, R. W. Tourdot, J. Li, M. Nakhoul, D. Gallant, U. A. Ahmed, J. O'Toole, D. Freeman, G.-S. M. Lee, J. Hecht, , S. R. Viswanathan

This study identifies a genetic basis for cancer sex differences in Xp11 translocation renal cell carcinoma by showing a 2:1 female:male ratio in TFE3 fusions involving the inactive X chromosome.

bioRxiv · Aug 4, 2023 · PreprintCancer Biology

ECM dimensionality tunes actin tension to modulate the endoplasmic reticulum and spheroid phenotype

F. Kai, G. Ou, R. W. Tourdot, C. Stashko, G. Gaietta, M. F. Swift, N. Volkmann, A. F. Long, Y. Han, H. H. Huang, J. J. Northey, A. M. Leidal, V. Viasnoff, D. M. Bryant, W. Guo, , V. M. Weaver

The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.

bioRxiv · Jul 14, 2021 · PreprintCell Biology

Mechanisms Generating Cancer Genome Complexity From A Single Cell Division Error

N. Umbreit, C.-Z. Zhang, L. D. Lynch, L. J. Blaine, A. M. Cheng, R. W. Tourdot, L. Sun, H. F. Almubarak, K. Judge, T. J. Mitchell, A. Spektor, D. Pellman

This study identifies a mutational cascade triggered by chromosome bridge formation that leads to chromothripsis and contributes to cancer genome complexity and sub-clonal heterogeneity.

bioRxiv · Nov 7, 2019Cancer Biology