Author

K. K. Jang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. Cadwell· 3 shared D. Ercelen· 2 shared J. Axelrad· 2 shared S. Gurunathan· 2 shared Y.-H. Chen· 2 shared A. Korman· 1 shared A. M. Keestra-Gounde· 1 shared C. Zhou· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

K. Cadwell

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness

K. K. Jang, D. Ercelen, J. Y. C. Cen Feng, S. Gurunathan, C. Zhou, A. Korman, L. Newell, D. Hudesman, D. R. Jones, P. Loke, J. E. Axelrad, K. Cadwell

This study uses patient-derived intestinal organoids to predict individual clinical responsiveness to tofacitinib in ulcerative colitis by assessing drug sensitivity and MATE1 expression.

bioRxiv · Mar 2, 2024Cell Biology

Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization

K. K. Jang, T. Heaney, M. London, Y. Ding, F. Yeung, D. Ercelen, Y.-H. Chen, J. Axelrad, S. Gurunathan, A. M. Keestra-Gounde, M. E. Griffin, H. C. Hang, K. Cadwell

The paper shows that overproduction of REG3 proteins in IBD flares reduces Enterococcus faecium, worsening inflammation by disrupting microbiota-immune interactions.

bioRxiv · Jan 29, 2023 · PreprintImmunology

Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection

K. K. Jang, M. E. Kaczmarek, S. Dallari, Y.-H. Chen, T. Tada, J. Axelrad, N. R. Landau, K. A. Stapleford, K. Cadwell

This study examines inter-individual variability in SARS-CoV-2 infection of intestinal organoids, finding that ACE2 expression levels determine susceptibility and that Omicron variant shows higher infectivity.

bioRxiv · Jul 16, 2021Cell Biology