Author

J. Axelrad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

K. Cadwell· 4 shared K. K. Jang· 2 shared Y.-H. Chen· 2 shared A. Hine· 1 shared A. M. Keestra-Gounde· 1 shared D. Dixit· 1 shared D. Ercelen· 1 shared D. Hudesman· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersImmunology

K. Cadwell

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Sphingosine 1-phosphate receptor 1 inhibition induces a pro-apoptotic signaling cascade in T cells

D. Dixit, V. M. Hallisey, E. Y. S. Zhu, M. Okuniewska, K. Cadwell, J. E. Chipuk, J. Axelrad, S. R. Schwab

This study shows that S1PR1 inhibition leads to T cell apoptosis by altering BCL2 family balance and JNK activity, with implications for immune responses in ulcerative colitis.

bioRxiv · Aug 21, 2023 · PreprintImmunology

Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization

K. K. Jang, T. Heaney, M. London, Y. Ding, F. Yeung, D. Ercelen, Y.-H. Chen, J. Axelrad, S. Gurunathan, A. M. Keestra-Gounde, M. E. Griffin, H. C. Hang, K. Cadwell

The paper shows that overproduction of REG3 proteins in IBD flares reduces Enterococcus faecium, worsening inflammation by disrupting microbiota-immune interactions.

bioRxiv · Jan 29, 2023 · PreprintImmunology

Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection

K. K. Jang, M. E. Kaczmarek, S. Dallari, Y.-H. Chen, T. Tada, J. Axelrad, N. R. Landau, K. A. Stapleford, K. Cadwell

This study examines inter-individual variability in SARS-CoV-2 infection of intestinal organoids, finding that ACE2 expression levels determine susceptibility and that Omicron variant shows higher infectivity.

bioRxiv · Jul 16, 2021Cell Biology

Transcriptional Atlas of Ileal-Anal Pouch Immune Cells from Ulcerative Colitis Patients

J. C. Devlin, J. Axelrad, A. Hine, S. Chang, S. Sarkar, J.-D. Lin, K. V. Ruggles, D. Hudesman, K. Cadwell, P. Loke

The paper uses single-cell RNA-sequencing to analyze immune cells in ileal pouches and colons of UC patients, identifying specific cell types and their association with inflammation and treatment response.

bioRxiv · Jul 31, 2020Immunology