Maintaining structural and functional homeostasis of the Drosophila respiratory epithelia requires stress-modulated JAK/STAT activity
X. Niu, C. Fink, K. Kallsen, L. Shi, V. Mincheva, S. Franzenburg, R. D. Prange, J. Bossen, H. Heine, T. Roeder
This study shows that balanced JAK/STAT signaling is essential for maintaining structural and functional homeostasis in Drosophila respiratory epithelia, while chronic overactivation leads to pathological changes resembling human lung diseases.
bioRxiv · Jun 19, 2020 · PreprintCell Biology