Author

H. Heine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:Drosophila· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. Fink· 3 shared T. Roeder· 3 shared J. Bossen· 2 shared R. D. Prange· 2 shared S. Franzenburg· 2 shared X. Niu· 2 shared A. Abdelsadik· 1 shared A. Gross· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersPhysiology

C. Fink

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

FoxO factors preserve airway epithelial homeostasis by coordinating adaptive stress responses

K. Uliczka, J. M. Bossen, U. Zissler, C. Fink, X. Niu, M. Pieper, R. D. Prange, C. Vock, C. Wagner, M. Knop, A. Abdelsadik, S. Franzenburg, I. Bruchhaus, M. Wegmann, C. B. Schmidt-Weber, , T. Roeder

The paper shows FoxO factors in Drosophila, mouse, and human airway epithelial cells respond to stressors by nuclear translocation, with FoxO-dependent stress pathways altered in asthma across species.

bioRxiv · Jan 31, 2024 · PreprintPhysiology

Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model

R. M. Pfefferkorn, B. M. Mortzfeld, C. Fink, J. von Frieling, J. Bossen, D. Esser, C. M. Kaleta, P. Rosenstiel, H. Heine, T. Roeder

The paper shows that cyclic severe protein restriction in Drosophila reduces tumor growth, restores gut function, and extends lifespan without the harmful effects of continuous restriction.

bioRxiv · Jan 18, 2023 · PreprintCancer Biology

WNT6-ACC2-induced accumulation of triacylglycerol rich lipid droplets is exploited by Mycobacterium tuberculosis

J. Brandenburg, S. Marwitz, S. C. Tazoll, F. Waldow, B. Kalsdorf, T. Vierbuchen, T. Scholzen, A. Gross, S. Goldenbaum, A. Hoelscher, M. Hein, L. Linnemann, M. Reimann, A. Kispert, M. Leitges, , N. Reiling

This study shows that the WNT6-ACC2 pathway promotes lipid droplet accumulation in macrophages, which Mycobacterium tuberculosis exploits for growth, and that inhibiting this pathway enhances anti-tuberculosis treatment.

bioRxiv · Jun 26, 2020 · PreprintImmunology

Maintaining structural and functional homeostasis of the Drosophila respiratory epithelia requires stress-modulated JAK/STAT activity

X. Niu, C. Fink, K. Kallsen, L. Shi, V. Mincheva, S. Franzenburg, R. D. Prange, J. Bossen, H. Heine, T. Roeder

This study shows that balanced JAK/STAT signaling is essential for maintaining structural and functional homeostasis in Drosophila respiratory epithelia, while chronic overactivation leads to pathological changes resembling human lung diseases.

bioRxiv · Jun 19, 2020 · PreprintCell Biology