Author

J. Bossen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

T. Roeder· 3 shared C. Fink· 2 shared H. Heine· 2 shared J. von Frieling· 2 shared A. Tholey· 1 shared B. M. Mortzfeld· 1 shared C. M. Kaleta· 1 shared C. Treitz· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

T. Roeder

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3 papers

Recent·Most cited

A mitochondrial sirtuin shapes the intestinal microbiota by controlling lysozyme expression

M. Knop, C. Treitz, S. Bettendorf, J. Bossen, J. von Frieling, S. Doms, I. Bruchhaus, R. Kuehnlein, J. F. Baines, A. Tholey, T. Roeder

This study shows that dSirt4 in Drosophila controls lysozyme expression in the intestine, altering microbiota composition and reducing lifespan.

bioRxiv · Jun 2, 2023 · PreprintCell Biology

Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model

R. M. Pfefferkorn, B. M. Mortzfeld, C. Fink, J. von Frieling, J. Bossen, D. Esser, C. M. Kaleta, P. Rosenstiel, H. Heine, T. Roeder

The paper shows that cyclic severe protein restriction in Drosophila reduces tumor growth, restores gut function, and extends lifespan without the harmful effects of continuous restriction.

bioRxiv · Jan 18, 2023 · PreprintCancer Biology

Maintaining structural and functional homeostasis of the Drosophila respiratory epithelia requires stress-modulated JAK/STAT activity

X. Niu, C. Fink, K. Kallsen, L. Shi, V. Mincheva, S. Franzenburg, R. D. Prange, J. Bossen, H. Heine, T. Roeder

This study shows that balanced JAK/STAT signaling is essential for maintaining structural and functional homeostasis in Drosophila respiratory epithelia, while chronic overactivation leads to pathological changes resembling human lung diseases.

bioRxiv · Jun 19, 2020 · PreprintCell Biology