K. Sugimoto

Two antagonistic gene regulatory networks drive Arabidopsis root hair growth at low temperature

This paper identifies two opposing gene regulatory networks that control root hair growth in Arabidopsis at low temperature, revealing their role in integrating environmental and internal signals.

Characterization of the placenta-specific EnvV2-Fca soluble protein derived from endogenous retrovirus

This study identifies and characterizes EnvV2-Fca, a placenta-specific protein from an endogenous retrovirus in cats, and explores its evolutionary and potential zoonotic implications.

Label-free ghost cytometry for manufacturing of cell therapy products

This paper introduces label-free ghost cytometry (LF-GC) for cell therapy manufacturing, showing it can quantify cell count, viability, and identify cell subsets and impurities without staining.

Enhancer evolution as a driving force for lineage-specific paralog usage in the central nervous system.

The paper investigates how enhancer evolution drives lineage-specific paralog usage in hypophysiotropic GnRH neurons across vertebrates, finding that enhancer loss, not regulatory changes, caused paralog role division.

TFIIF interacts with the Topoisomerase VI complex and selectively controls the expression of genes encoding PPR proteins involved in organellar RNA editing in Arabidopsis.

This study identifies TFIIF's role in regulating PPR gene expression in Arabidopsis, showing its interaction with Topo VI and impact on plastid RNA editing and NDH activity.

A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis

This study identifies a transcriptional network involving SCL28 and AtSMOS1 that regulates cell size and number in Arabidopsis by controlling G2 phase transitions through CDK inhibitors.

High temperature perception in leaves promotes vascular regeneration in distant tissues

This study shows elevated temperatures enhance vascular regeneration in plant grafts, mediated by leaf-derived auxin, and this effect is not limited to graft healing.

GTL1 is required for a robust root hair growth response to avoid nutrient overloading

The paper shows that GTL1 and DF1 prevent excessive root hair growth by repressing RSL4 under high nutrient conditions.

Transcriptional activation of auxin biosynthesis drives developmental reprogramming of differentiated cells

This study shows that activating auxin biosynthesis transcription is essential for reprogramming differentiated Arabidopsis leaf cells to pluripotency by reactivating the cell cycle.

Association between the extent of DNA methylation at the CpG sites of HIF3A and parameters of obesity in the general Japanese population

The paper examines the association between DNA methylation at HIF3A CpG sites and obesity parameters in Japanese women, finding a link between methylation at cg27146050 and visceral fat thickness, BMI, and body fat percentage.

Spatial transcriptional signatures define margin morphogenesis along the proximal-distal and medio-lateral axes in complex leaf species Solanum lycopersicum (tomato)

The paper uses structural characterization, laser capture microdissection, and transcriptomic sequencing to reveal gene expression patterns regulating early compound leaf morphogenesis in tomato.

Aberrant claudin-6-adhesion signal promotes endometrial cancer progression via estrogen receptor α

The paper shows that CLDN6 promotes endometrial cancer progression by activating estrogen receptor α through SFK/PI3K signaling, independent of ligand.

Within and cross species predictions of plant specialized metabolism genes using transfer learning

The paper uses transfer learning to predict specialized metabolism genes in tomato by leveraging annotations from Arabidopsis thaliana, improving prediction accuracy.

Topoisomerase VI participates in an insulator-like function that prevents H3K9me2 spreading into euchromatic islands

The paper shows Topoisomerase VI prevents H3K9me2 spreading into euchromatic islands in Arabidopsis by interacting with MAT3 and regulating its localization.

Unleashing floret fertility by a mutated homeobox gene improved grain yield during wheat evolution under domestication

This study identifies GNI1, a homeobox gene whose mutations increased floret fertility and grain yield in wheat during domestication.

Regulatory Divergence In Wound-Responsive Gene Expression In Domesticated And Wild Tomato

This study identifies cis- and trans-regulatory divergence in wound-responsive gene expression between wild and domesticated tomato species.