OTUD1 deubiquitylase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways
D. Oikawa, M. Gi, H. Kosako, K. Shimizu, H. Takahashi, M. Shiota, S. Hosomi, K. Komakura, H. Wanibuchi, D. Tsuruta, T. Sawasaki, F. Tokunaga
This study identifies OTUD1 as a deubiquitylase that suppresses NF-κB and KEAP1-mediated inflammatory and oxidative stress responses, while promoting antiviral pathways and ROS-associated cell death.
bioRxiv · Dec 26, 2021 · PreprintCell Biology